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Journal of Biomedical Optics

Methylene blue microbubbles as a model dual-modality contrast agent for ultrasound and activatable photoacoustic imaging
Author(s): Mansik Jeon; Wentao Song; Elizabeth Huynh; Jungho Kim; Jeesu Kim; Brandon L. Helfield; Benjamin Y. C. Leung; David E. Geortz; Gang Zheng; Jungtaek Oh; Jonathan F. Lovell; Chulhong Kim
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Paper Abstract

Ultrasound and photoacoustic imaging are highly complementary modalities since both use ultrasonic detection for operation. Increasingly, photoacoustic and ultrasound have been integrated in terms of hardware instrumentation. To generate a broadly accessible dual-modality contrast agent, we generated microbubbles (a standard ultrasound contrast agent) in a solution of methylene blue (a standard photoacoustic dye). This MB 2 solution was formed effectively and was optimized as a dual-modality contrast solution. As microbubble concentration increased (with methylene blue concentration constant), photoacoustic signal was attenuated in the MB 2 solution. When methylene blue concentration increased (with microbubble concentration held constant), no ultrasonic interference was observed. Using an MB 2 solution that strongly attenuated all photoacoustic signal, high powered ultrasound could be used to burst the microbubbles and dramatically enhance photoacoustic contrast (<800 -fold increase), providing a new method for spatiotemporal control of photoacoustic signal generation.

Paper Details

Date Published: 6 January 2014
PDF: 9 pages
J. Biomed. Opt. 19(1) 016005 doi: 10.1117/1.JBO.19.1.016005
Published in: Journal of Biomedical Optics Volume 19, Issue 1
Show Author Affiliations
Mansik Jeon, Pohang Univ. of Science and Technology (Korea, Republic of)
Wentao Song, Univ. at Buffalo (United States)
Elizabeth Huynh, Univ. Health Network (Canada)
Jungho Kim, Samsung Medison (Korea, Republic of)
Jeesu Kim, Pohang Univ. of Science and Technology (Korea, Republic of)
Brandon L. Helfield, Univ. of Toronto (Canada)
Benjamin Y. C. Leung, Sunnybrook Health Sciences Ctr. (Canada)
David E. Geortz, Univ. of Toronto (Canada)
Gang Zheng, Univ. of Toronto (Canada)
Jungtaek Oh, Samsung Medison (Korea, Republic of)
Jonathan F. Lovell, Univ. at Buffalo (United States)
Chulhong Kim, Pohang Univ. of Science and Technology (Korea, Republic of)

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