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Journal of Biomedical Optics

Deep-tissue light delivery via optrode arrays
Author(s): Tanya Vanessa F. Abaya; Mohit Diwekar; Steve Blair; Prashant Tathireddy; Loren Rieth; Florian Solzbacher
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Paper Abstract

We establish performance characteristics of needle-type waveguides in three-dimensional array architectures as light delivery interfaces into deep tissue for applications, such as optogenetic and infrared (IR) neural stimulation. A single optrode waveguide achieves as high as 90% transmission efficiency, even at tissue depths <1  mm . Throughout the visible and near-IR spectrum, the effective light attenuation through the waveguide is ∼3 orders of magnitude smaller than attenuation in tissue/water, as confirmed by both simulation and experimental results. Light emission profiles from the optrode tips into tissue were also measured. Beam widths of 70 to 150 μm and full-angle divergence ranging from 13 to 40 deg in tissue can be achieved. These beam characteristics satisfy a wide range of requirements for targeted illumination in neural stimulation.

Paper Details

Date Published: 9 January 2014
PDF: 10 pages
J. Biomed. Opt. 19(1) 015006 doi: 10.1117/1.JBO.19.1.015006
Published in: Journal of Biomedical Optics Volume 19, Issue 1
Show Author Affiliations
Tanya Vanessa F. Abaya, The Univ. of Utah (United States)
Mohit Diwekar, The Univ. of Utah (United States)
Steve Blair, The Univ. of Utah (United States)
Prashant Tathireddy, The Univ. of Utah (United States)
Loren Rieth, The Univ. of Utah (United States)
Florian Solzbacher, The Univ. of Utah (United States)

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