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Journal of Biomedical Optics • Open Access

Discriminant analysis of functional optical topography for schizophrenia diagnosis
Author(s): Ching-Cheng Chuang; Kazuyuki Nakagome; Shenghong Pu; Tsuo-Hung Lan; Chia-Yen Lee; Chia-Wei Sun

Paper Abstract

Abnormal prefrontal function plays a central role in the cognition deficits of schizophrenic patients; however, the character of the relationship between discriminant analysis and prefrontal activation remains undetermined. Recently, evidence of low prefrontal cortex (PFC) activation in individuals with schizophrenia has also been found during verbal fluency tests (VFT) and other cognitive tests with several neuroimaging methods. The purpose of this study is to assess the hemodynamic changes of the PFC and discriminant analysis between schizophrenia patients and healthy controls during VFT task by utilizing functional optical topography. A total of 99 subjects including 53 schizophrenic patients and 46 age- and gender-matched healthy controls were studied. The results showed that the healthy group had larger activation in the right and left PFC than in the middle PFC. Besides, the schizophrenic group showed weaker task performance and lower activation in the whole PFC than the healthy group. The result of the discriminant analysis showed a significant difference with P value <0.001 in six channels (CH 23, 29, 31, 40, 42, 52) between the schizophrenic and healthy groups. Finally, 68.69% and 71.72% of subjects are correctly classified as being schizophrenic or healthy with all 52 channels and six significantly different channels, respectively. Our findings suggest that the left PFC can be a feature region for discriminant analysis of schizophrenic diagnosis.

Paper Details

Date Published: 29 August 2013
PDF: 6 pages
J. Biomed. Opt. 19(1) 011006 doi: 10.1117/1.JBO.19.1.011006
Published in: Journal of Biomedical Optics Volume 19, Issue 1
Show Author Affiliations
Ching-Cheng Chuang, National Yang-Ming Univ. (Taiwan)
Kazuyuki Nakagome
Shenghong Pu, Tottori Univ. (Japan)
Tsuo-Hung Lan, National Yang-Ming Univ. (Taiwan)
Chia-Yen Lee, National United Univ. (Taiwan)
Chia-Wei Sun, National Chiao Tung Univ. (Taiwan)

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