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Journal of Biomedical Optics • Open Access

Fast segmentation and high-quality three-dimensional volume mesh creation from medical images for diffuse optical tomography
Author(s): Michael Jermyn; Hamid R. Ghadyani; Michael A. Mastanduno; Wesley D. Turner; Scott C. Davis; Hamid Dehghani; Brian W. Pogue

Paper Abstract

Multimodal approaches that combine near-infrared (NIR) and conventional imaging modalities have been shown to improve optical parameter estimation dramatically and thus represent a prevailing trend in NIR imaging. These approaches typically involve applying anatomical templates from magnetic resonance imaging/computed tomography/ultrasound images to guide the recovery of optical parameters. However, merging these data sets using current technology requires multiple software packages, substantial expertise, significant time-commitment, and often results in unacceptably poor mesh quality for optical image reconstruction, a reality that represents a significant roadblock for translational research of multimodal NIR imaging. This work addresses these challenges directly by introducing automated digital imaging and communications in medicine image stack segmentation and a new one-click three-dimensional mesh generator optimized for multimodal NIR imaging, and combining these capabilities into a single software package (available for free download) with a streamlined workflow. Image processing time and mesh quality benchmarks were examined for four common multimodal NIR use-cases (breast, brain, pancreas, and small animal) and were compared to a commercial image processing package. Applying these tools resulted in a fivefold decrease in image processing time and 62% improvement in minimum mesh quality, in the absence of extra mesh postprocessing. These capabilities represent a significant step toward enabling translational multimodal NIR research for both expert and nonexpert users in an open-source platform.

Paper Details

Date Published: 12 August 2013
PDF: 11 pages
J. Biomed. Opt. 18(8) 086007 doi: 10.1117/1.JBO.18.8.086007
Published in: Journal of Biomedical Optics Volume 18, Issue 8
Show Author Affiliations
Michael Jermyn, Thayer School of Engineering at Dartmouth (United States)
Hamid R. Ghadyani, Thayer School of Engineering at Dartmouth (United States)
Michael A. Mastanduno, Thayer School of Engineering at Dartmouth (United States)
Wesley D. Turner, Kitware, Inc. (United States)
Scott C. Davis, Thayer School of Engineering at Dartmouth (United States)
Hamid Dehghani, The Univ. of Birmingham (United Kingdom)
Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)


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