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Journal of Biomedical Optics • Open Access

Combined two-photon microscopy and angiographic optical coherence tomography

Paper Abstract

A combined two-photon microscopy (TPM) and angiographic optical coherence tomography (OCT) is developed, which can provide molecular, cellular, structural, and vascular information of tissue specimens in vivo. This combined system is implemented by adding an OCT vasculature visualization method to the previous combined TPM and OCT, and then is applied to in vivo tissue imaging. Two animal models, a mouse brain cranial window model and a mouse ear cancer model, are used. Both molecular, cellular information at local regions of tissues, and structural, vascular information at relatively larger regions are visualized in the same sections. In vivo tissue microenvironments are better elucidated by the combined TPM and angiographic OCT.

Paper Details

Date Published: 7 August 2013
PDF: 3 pages
J. Biomed. Opt. 18(8) 080502 doi: 10.1117/1.JBO.18.8.080502
Published in: Journal of Biomedical Optics Volume 18, Issue 8
Show Author Affiliations
Bumju Kim, Pohang Univ. of Science and Technology (Korea, Republic of)
Taejun Wang, Pohang Univ. of Science and Technology (Korea, Republic of)
Qingyun Li, Pohang Univ. of Science and Technology (Korea, Republic of)
Jutaek Nam, Pohang Univ. of Science and Technology (Korea, Republic of)
Sekyu Hwang, Pohang Univ. of Science and Technology (Korea, Republic of)
Euiheon Chung, Gwangju Institute of Science and Technology (Korea, Republic of)
Sungjee Kim, Pohang Univ. of Science and Technology (Korea, Republic of)
Ki Hean Kim, Pohang Univ. of Science and Technology (Korea, Republic of)


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