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Journal of Biomedical Optics • Open Access

Two-photon excited quantum dots as energy donors for photosensitizer chlorin e6
Author(s): Artiom Skripka; Jurga Valanciunaite; Gediminas Dauderis; Vilius Poderys; Reda Kubiliute; Ricardas Rotomskis

Paper Abstract

The excitation-related problems in photodynamic therapy of cancer might be solved by combining two-photon (TP) irradiation and quantum dots (QDs) as effective energy donors for conventional photosensitizers (PS). Here, it is demonstrated for the first time that QD–chlorin e 6 (Ce 6 ) complex formed due to the hydrophobic interaction between Ce 6 molecules and lipid coating of QDs can be effectively excited via TP irradiation at 1030 nm, which spectrally coincides with the biological tissue optical window. TP absorption cross-section for free QDs and Ce 6 at 1030 nm was 3325 and 13 Goeppert-Mayer, respectively. Upon TP excitation of QD−Ce 6 solution, the fluorescence band of bound Ce 6 molecules was observed via energy transfer from excited QDs. Increasing concentration of Ce 6 resulted in quenching of the photoluminescence of QDs and an increase in the fluorescence intensity of bound Ce 6 molecules. These intensity changes coincided well with those observed upon single-photon excitation of QD−Ce 6 solution when QDs alone are excited. The efficiency of energy transfer in QD−Ce 6 complex upon TP excitation was about 80% (QD∶Ce 6 1∶5 ). These results indicate that the effective excitation of PS with a low TP absorption cross-section is possible in such type noncovalent complexes via energy transfer from TP excited QDs.

Paper Details

Date Published: 17 July 2013
PDF: 5 pages
J. Biomed. Opt. 18(7) 078002 doi: 10.1117/1.JBO.18.7.078002
Published in: Journal of Biomedical Optics Volume 18, Issue 7
Show Author Affiliations
Artiom Skripka, Vilnius Univ. (Lithuania)
Jurga Valanciunaite, Vilnius Univ. (Lithuania)
Gediminas Dauderis, Vilnius Univ. (Lithuania)
Vilius Poderys, Vilnius Univ. (Lithuania)
Reda Kubiliute, Vilnius Univ. (Lithuania)
Ricardas Rotomskis, Vilnius Univ. (Lithuania)

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