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Journal of Biomedical Optics • Open Access

Terahertz spectroscopy for the assessment of burn injuries in vivo
Author(s): M. Hassan Arbab; Dale P. Winebrenner; Trevor C. Dickey; Antao Chen; Matthew B. Klein; Pierre D. Mourad

Paper Abstract

A diagnosis criterion is proposed for noninvasive grading of burn injuries using terahertz radiation. Experimental results are presented from in vivo terahertz time-domain spectroscopy of second- and third-degree wounds, which are obtained in a 72-hour animal study. During this period, the change in the spectroscopic response of the burned tissue is studied. It is shown that terahertz waves are sensitive not only to the postburn formation of interstitial edema, but also to the density of skin structures derived from image processing analysis of histological sections. Based on these preliminary results, it is suggested that the combination of these two effects, as probed by terahertz spectroscopy of the tissue, may ultimately be used to differentiate partial-thickness burns that will naturally heal from those that will require surgical intervention.

Paper Details

Date Published: 16 July 2013
PDF: 8 pages
J. Biomed. Opt. 18(7) 077004 doi: 10.1117/1.JBO.18.7.077004
Published in: Journal of Biomedical Optics Volume 18, Issue 7
Show Author Affiliations
M. Hassan Arbab, Univ. of Washington (United States)
Dale P. Winebrenner, Univ. of Washington (United States)
Trevor C. Dickey, Univ. of Washington (United States)
Antao Chen, Univ. of Washington (United States)
Matthew B. Klein, Univ. of Washington (United States)
Pierre D. Mourad, Univ. of Washington (United States)

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