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Journal of Biomedical Optics

Usefulness of tissue autofluorescence imaging in actinic cheilitis diagnosis
Author(s): Ademar Takahama; Cristina Kurachi; Alessandro Cosci; Isabel Schausltz Pereira Faustino; Danielle Resende Camisasca; Karla B. F. da Costa Fontes Fontes; Fabio Ramoa Pires; Rebeca Souza Azevedo
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Paper Abstract

Actinic cheilitis (AC) is a potentially malignant disorder of the lips. Because of its heterogeneous clinical aspect, it is difficult to indicate representative biopsy area. The purpose of this study was to evaluate the usefulness of tissue autofluorescence in AC diagnosis. The system was composed of a 405-nm light-emitting diode, sent to the sample by a dichroic, that allows the fluorescence signal to reach a camera directly plugged in the system. Fifty-seven patients with clinical diagnosis of AC and 45 normal volunteers were selected. According to clinical and fluorescence features, one or more areas were selected for biopsies in the AC group and epithelial dysplasia (ED) grades were established. The autofluorescence images were processed by a clustering algorithm for AC automated diagnosis. The tissue autofluorescence image revealed a heterogeneous pattern of loss and increase of fluorescence in patients with AC. ED was found in 93% of the cases, and most of the areas graded as moderate or severe ED were chosen with the aid of autofluorescence. The processed autofluorescence images from AC patients showed a higher number of spots in an irregular pattern. Tissue autofluorescence image system is a useful technique in association with clinical examination for AC diagnosis.

Paper Details

Date Published: 25 July 2013
PDF: 7 pages
J. Biomed. Opt. 18(7) 076023 doi: 10.1117/1.JBO.18.7.076023
Published in: Journal of Biomedical Optics Volume 18, Issue 7
Show Author Affiliations
Ademar Takahama, Univ. Federal Fluminense (Brazil)
Cristina Kurachi, Univ. de São Paulo (Brazil)
Alessandro Cosci, Univ. de São Paulo (Brazil)
Isabel Schausltz Pereira Faustino
Danielle Resende Camisasca, Univ. Federal Fluminense (Brazil)
Karla B. F. da Costa Fontes Fontes
Fabio Ramoa Pires, UERJ (Brazil)
Rebeca Souza Azevedo

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