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Journal of Biomedical Optics • Open Access

Optical imaging of acute epileptic networks in mice

Paper Abstract

The potential of intrinsic optical imaging and resting-state analysis under anesthetized conditions as a tool to study brain networks associated with epileptic seizures is investigated. Using an acute model of epileptiform activity, the 4-aminopyridine model in live mice, we observe the changes in resting-state networks with the onset of seizure activity and in conditions of spiking activity. Resting-state networks identified before and after the onset of epileptiform activity show both decreased and increased homologous correlations, with a small dependence on seizure intensity. The observed changes are not uniform across the different hemodynamic measures, suggesting a potential decoupling between blood flow and metabolism in the low-frequency networks. This study supports the need for a more extensive investigation of epileptic networks including more than one independent hemodynamic measurement.

Paper Details

Date Published: 25 July 2013
PDF: 8 pages
J. Biomed. Opt. 18(7) 076021 doi: 10.1117/1.JBO.18.7.076021
Published in: Journal of Biomedical Optics Volume 18, Issue 7
Show Author Affiliations
Edgar Guevara, Ecole Polytechnique de Montréal (Canada)
Philippe Pouliot, Ecole Polytechnique de Montréal (Canada)
Dang Nguyen, Ctr. Hospitalier de l'Univ. de Montréal (Canada)
Frédéric Lesage, Ecole Polytechnique de Montréal (Canada)

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