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Journal of Biomedical Optics

Use of Split Bregman denoising for iterative reconstruction in fluorescence diffuse optical tomography
Author(s): Judit Chamorro-Servent; Juan F. Abascal; Juan Aguirre; Simon R. Arridge; Teresa M. Correia; Jorge Ripoll; Manuel Desco; Juan Jose Vaquero
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Paper Abstract

Fluorescence diffuse optical tomography (fDOT) is a noninvasive imaging technique that makes it possible to quantify the spatial distribution of fluorescent tracers in small animals. fDOT image reconstruction is commonly performed by means of iterative methods such as the algebraic reconstruction technique (ART). The useful results yielded by more advanced l 1 -regularized techniques for signal recovery and image reconstruction, together with the recent publication of Split Bregman (SB) procedure, led us to propose a new approach to the fDOT inverse problem, namely, ART-SB. This method alternates a cost-efficient reconstruction step (ART iteration) with a denoising filtering step based on minimization of total variation of the image using the SB method, which can be solved efficiently and quickly. We applied this method to simulated and experimental fDOT data and found that ART-SB provides substantial benefits over conventional ART.

Paper Details

Date Published: 17 July 2013
PDF: 9 pages
J. Biomed. Opt. 18(7) 076016 doi: 10.1117/1.JBO.18.7.076016
Published in: Journal of Biomedical Optics Volume 18, Issue 7
Show Author Affiliations
Judit Chamorro-Servent, Univ. Carlos III de Madrid (Spain)
Juan F. Abascal, Univ. Carlos III de Madrid (Spain)
Juan Aguirre, Ctr. de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (Spain)
Simon R. Arridge, Univ. College London (United Kingdom)
Teresa M. Correia, Univ. College London (United Kingdom)
Jorge Ripoll, Univ. Carlos III de Madrid (Spain)
Manuel Desco, Univ. Carlos III de Madrid (Spain)
Juan Jose Vaquero, Univ. Carlos III de Madrid (Spain)

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