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Journal of Biomedical Optics • Open Access

Optimization of confocal scanning laser ophthalmoscope design
Author(s): Francesco LaRocca; Al-Hafeez Dhalla; Michael P. Kelly; Sina Farsiu; Jerald A. Izatt

Paper Abstract

Confocal scanning laser ophthalmoscopy (cSLO) enables high-resolution and high-contrast imaging of the retina by employing spatial filtering for scattered light rejection. However, to obtain optimized image quality, one must design the cSLO around scanner technology limitations and minimize the effects of ocular aberrations and imaging artifacts. We describe a cSLO design methodology resulting in a simple, relatively inexpensive, and compact lens-based cSLO design optimized to balance resolution and throughput for a 20-deg field of view (FOV) with minimal imaging artifacts. We tested the imaging capabilities of our cSLO design with an experimental setup from which we obtained fast and high signal-to-noise ratio (SNR) retinal images. At lower FOVs, we were able to visualize parafoveal cone photoreceptors and nerve fiber bundles even without the use of adaptive optics. Through an experiment comparing our optimized cSLO design to a commercial cSLO system, we show that our design demonstrates a significant improvement in both image quality and resolution.

Paper Details

Date Published: 17 July 2013
PDF: 10 pages
J. Biomed. Opt. 18(7) 076015 doi: 10.1117/1.JBO.18.7.076015
Published in: Journal of Biomedical Optics Volume 18, Issue 7
Show Author Affiliations
Francesco LaRocca, Duke Univ. (United States)
Al-Hafeez Dhalla, Duke Univ. (United States)
Michael P. Kelly, Duke Univ. Medical Ctr. (United States)
Sina Farsiu, Duke Univ. (United States)
Jerald A. Izatt, Duke Univ. Medical Ctr. (United States)

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