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Journal of Biomedical Optics

Early detection of high-grade squamous intraepithelial lesions in the cervix with quantitative spectroscopic imaging
Author(s): Condon Lau; Jelena Mirkovic; Chung-Chief Yu; Geoffrey P. O'Donoghue; Luis Galindo; Ramachandra R. Dasari; Antonio de las Morenas; Michael S. Feld; Elizabeth Stier
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Paper Abstract

Quantitative spectroscopy has recently been extended from a contact-probe to wide-area spectroscopic imaging to enable mapping of optical properties across a wide area of tissue. We train quantitative spectroscopic imaging (QSI) to identify cervical high-grade squamous intraepithelial lesions (HSILs) in 34 subjects undergoing the loop electrosurgical excision procedure (LEEP subjects). QSI’s performance is then prospectively evaluated on the clinically suspicious biopsy sites from 47 subjects undergoing colposcopic-directed biopsy. The results show the per-subject normalized reduced scattering coefficient at 700 nm (A n) and the total hemoglobin concentration are significantly different (p<0.05 ) between HSIL and non-HSIL sites in LEEP subjects. A n alone retrospectively distinguishes HSIL from non-HSIL with 89% sensitivity and 83% specificity. It alone applied prospectively on the biopsy sites distinguishes HSIL from non-HSIL with 81% sensitivity and 78% specificity. The findings of this study agree with those of an earlier contact-probe study, validating the robustness of QSI, and specifically A n , for identifying HSIL. The performance of A n suggests an easy to use and an inexpensive to manufacture monochromatic instrument is capable of early cervical cancer detection, which could be used as a screening and diagnostic tool for detecting cervical cancer in low resource countries.

Paper Details

Date Published: 10 July 2013
PDF: 9 pages
J. Biomed. Opt. 18(7) 076013 doi: 10.1117/1.JBO.18.7.076013
Published in: Journal of Biomedical Optics Volume 18, Issue 7
Show Author Affiliations
Condon Lau, Massachusetts Institute of Technology (United States)
Jelena Mirkovic, Massachusetts Institute of Technology (United States)
Chung-Chief Yu, Massachusetts Institute of Technology (United States)
Geoffrey P. O'Donoghue, Massachusetts Institute of Technology (United States)
Luis Galindo, Massachusetts Institute of Technology (United States)
Ramachandra R. Dasari, Massachusetts Institute of Technology (United States)
Antonio de las Morenas, Boston Medical Ctr. (United States)
Michael S. Feld, Massachusetts Institute of Technology (United States)
Elizabeth Stier, Boston Medical Ctr. (United States)


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