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Journal of Biomedical Optics

Pilot study assessment of dynamic vascular changes in breast cancer with near-infrared tomography from prospectively targeted manipulations of inspired end-tidal partial pressure of oxygen and carbon dioxide
Author(s): Shudong Jiang; Brian W. Pogue; Kelly E. Michaelsen; Michael Jermyn; Michael A. Mastanduno; Tracy E. Frazee; Peter A. Kaufman; Keith D. Paulsen
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Paper Abstract

The dynamic vascular changes in the breast resulting from manipulation of both inspired end-tidal partial pressure of oxygen and carbon dioxide were imaged using a 30 s per frame frequency-domain near-infrared spectral (NIRS) tomography system. By analyzing the images from five subjects with asymptomatic mammography under different inspired gas stimulation sequences, the mixture that maximized tissue vascular and oxygenation changes was established. These results indicate maximum changes in deoxy-hemoglobin, oxygen saturation, and total hemoglobin of 21, 9, and 3%, respectively. Using this inspired gas manipulation sequence, an individual case study of a subject with locally advanced breast cancer undergoing neoadjuvant chemotherapy (NAC) was analyzed. Dynamic NIRS imaging was performed at different time points during treatment. The maximum tumor dynamic changes in deoxy-hemoglobin increased from less than 7% at cycle 1, day 5 (C1, D5) to 17% at (C1, D28), which indicated a complete response to NAC early during treatment and was subsequently confirmed pathologically at the time of surgery.

Paper Details

Date Published: 10 July 2013
PDF: 8 pages
J. Biomed. Opt. 18(7) 076011 doi: 10.1117/1.JBO.18.7.076011
Published in: Journal of Biomedical Optics Volume 18, Issue 7
Show Author Affiliations
Shudong Jiang, Thayer School of Engineering at Dartmouth (United States)
Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)
Kelly E. Michaelsen, Thayer School of Engineering at Dartmouth (United States)
Michael Jermyn, Thayer School of Engineering at Dartmouth (United States)
Michael A. Mastanduno, Thayer School of Engineering at Dartmouth (United States)
Tracy E. Frazee, Dartmouth Hitchcock Medical Ctr. (United States)
Peter A. Kaufman, Dartmouth Hitchcock Medical Ctr. (United States)
Keith D. Paulsen, Thayer School of Engineering at Dartmouth (United States)


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