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Journal of Biomedical Optics

Dynamic model of thermal reaction of biological tissues to laser-induced fluorescence and photodynamic therapy
Author(s): Alexey Y. Seteikin; Ilya V. Krasnikov; Eleni A. Drakaki; Mersini Makropoulou
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Paper Abstract

The aim of this work was to evaluate the temperature fields and the dynamics of heat conduction into the skin tissue under several laser irradiation conditions with both a pulsed ultraviolet (UV) laser (λ=337  nm ) and a continuous-wave (cw) visible laser beam =632.8  nm ) using Monte Carlo modeling. Finite-element methodology was used for heat transfer simulation. The analysis of the results showed that heat is not localized on the surface, but is collected inside the tissue in lower skin layers. The simulation was made with the pulsed UV laser beam (used as excitation source in laser-induced fluorescence) and the cw visible laser (used in photodynamic therapy treatments), in order to study the possible thermal effects.

Paper Details

Date Published: 9 July 2013
PDF: 9 pages
J. Biomed. Opt. 18(7) 075002 doi: 10.1117/1.JBO.18.7.075002
Published in: Journal of Biomedical Optics Volume 18, Issue 7
Show Author Affiliations
Alexey Y. Seteikin, Kwangwoon Univ. (Korea, Republic of)
Ilya V. Krasnikov, Amur State Univ. (Russian Federation)
Eleni A. Drakaki, National Technical Univ. of Athens (Greece)
Mersini Makropoulou, National Technical Univ. of Athens (Greece)


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