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Journal of Biomedical Optics • Open Access

New model of subconjunctival tumor development in rabbits
Author(s): Sang Seok Hwang; Jeong Eun Kim; Bong-Kwon Chun; Sangbong Jung; Eun-Kee Park; Hu-Jang Lee; Mannhohng Jung; Sang-Joon Lee; Gwang Myung Noh; Rangarirai Masanganise; Chulho Oak; Yeh-Chan Ahn

Paper Abstract

Conjunctival squamous cell carcinoma (SCC) is an uncommon disease. However, SCC has recently become an important clinical problem due the identification of a significantly high incidence of SCC among a group of black African patients with AIDS. However, basic research concerning SCC, including both intraepithelial and invasive squamous neoplasia, is limited due to the lack of an ocular tumor animal model. Specifically, current ocular imaging and treatment modalities are insufficient for investigating currently available small animal models, because the conjunctival space is not comparable to that of humans. We describe the development of a reproducible model of subconjunctival squamous carcinoma in moderate-sized immunocompetent rabbits. Under optical coherence tomography guidance, 1×10 7 VX2 carcinoma cells are inoculated into the subconjunctival space of 3 to 4-kg New Zealand white rabbits. Malignant tumor involvement developed on the subconjunctival space after an average of 1 to 2 weeks. This subconjunctival tumor model induction method will likely facilitate a broad range of investigation of subconjunctival cancer diagnostics and therapeutics.

Paper Details

Date Published: 1 July 2013
PDF: 5 pages
J. Biomed. Opt. 18(7) 070501 doi: 10.1117/1.JBO.18.7.070501
Published in: Journal of Biomedical Optics Volume 18, Issue 7
Show Author Affiliations
Sang Seok Hwang, Pukyong National Univ. (Korea, Republic of)
Jeong Eun Kim, Pukyong National Univ. (Korea, Republic of)
Bong-Kwon Chun, Kosin Univ. College of Medicine (Korea, Republic of)
Sangbong Jung, Gimhae College (Korea, Republic of)
Eun-Kee Park, Kosin Univ. College of Medicine (Korea, Republic of)
Hu-Jang Lee, Gyeongsang National Univ. (Korea, Republic of)
Mannhohng Jung, Kosin Univ. College of Medicine (Korea, Republic of)
Sang-Joon Lee, Kosin Univ. College of Medicine (Korea, Republic of)
Gwang Myung Noh, Kosin Univ. College of Medicine (Korea, Republic of)
Rangarirai Masanganise, Univ. of Zimbabwe College of Medicine (Zimbabwe)
Chulho Oak, Kosin Univ. College of Medicine (Korea, Republic of)
Yeh-Chan Ahn, Pukyong National Univ. (Korea, Republic of)


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