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Journal of Biomedical Optics • Open Access

Phantoms for diffuse optical imaging based on totally absorbing objects, part 1: basic concepts

Paper Abstract

The design of inhomogeneous phantoms for diffuse optical imaging purposes using totally absorbing objects embedded in a diffusive medium is proposed and validated. From time-resolved and continuous-wave Monte Carlo simulations, it is shown that a given or desired perturbation strength caused by a realistic absorbing inhomogeneity of a certain absorption and volume can be approximately mimicked by a small totally absorbing object of a so-called equivalent black volume (equivalence relation). This concept can be useful in two ways. First, it can be exploited to design realistic inhomogeneous phantoms with different perturbation strengths simply using a set of black objects with different volumes. Further, it permits one to grade physiological or pathological changes on a reproducible scale of perturbation strengths given as equivalent black volumes, thus facilitating the performance assessment of clinical instruments. A set of plots and interpolating functions to derive the equivalent black volume corresponding to a given absorption change is provided. The application of the equivalent black volume concept for grading different optical perturbations is demonstrated for some examples.

Paper Details

Date Published: 18 June 2013
PDF: 12 pages
J. Biomed. Opt. 18(6) 066014 doi: 10.1117/1.JBO.18.6.066014
Published in: Journal of Biomedical Optics Volume 18, Issue 6
Show Author Affiliations
Fabrizio Martelli, Univ. degli Studi di Firenze (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)
Davide Contini, Politecnico di Milano (Italy)
Lorenzo Spinelli, Istituto di Fotonica e Nanotecnologie (Italy)
Alessandro Torricelli, Politecnico di Milano (Italy)
Heidrun Wabnitz, Physikalisch-Technische Bundesanstalt (Germany)
Rainer Macdonald, Physikalisch-Technische Bundesanstalt (Germany)
Angelo Sassaroli, Tufts Univ. (United States)
Giovanni Zaccanti, Univ. degli Studi di Firenze (Italy)


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