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Journal of Biomedical Optics

Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity
Author(s): John Quan M. Nguyen; Christian Crouzet; Tuan Mai; Kathleen Riola; Daniel Uchitel; Lih-Huei L. Liaw; Nicole Bernal; Adrien Ponticorvo; Bernard Choi; Anthony J. Durkin
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Paper Abstract

Frequent monitoring of early-stage burns is necessary for deciding optimal treatment and management. Both superficial and full thickness burns are relatively easy to diagnose based on clinical observation. In between these two extremes are superficial-partial thickness and deep-partial thickness burns. These burns, while visually similar, differ dramatically in terms of clinical treatment and are known to progress in severity over time. The objective of this study was to determine the potential of spatial frequency domain imaging (SFDI) for noninvasively mapping quantitative changes in chromophore and optical properties that may be an indicative of burn wound severity. A controlled protocol of graded burn severity was developed and applied to 17 rats. SFDI data was acquired at multiple near-infrared wavelengths over a course of 3 h. Burn severity was verified using hematoxylin and eosin histology. From this study, we found that changes in water concentration (edema), deoxygenated hemoglobin concentration, and optical scattering (tissue denaturation) to be statistically significant at differentiating superficial partial-thickness burns from deep-partial thickness burns.

Paper Details

Date Published: 13 June 2013
PDF: 8 pages
J. Biomed. Opt. 18(6) 066010 doi: 10.1117/1.JBO.18.6.066010
Published in: Journal of Biomedical Optics Volume 18, Issue 6
Show Author Affiliations
John Quan M. Nguyen, Beckman Laser Institute and Medical Clinic (United States)
Christian Crouzet, Beckman Laser Institute and Medical Clinic (United States)
Tuan Mai, Beckman Laser Institute and Medical Clinic (United States)
Kathleen Riola, Beckman Laser Institute and Medical Clinic (United States)
Daniel Uchitel, Beckman Laser Institute and Medical Clinic (United States)
Lih-Huei L. Liaw, Beckman Laser Institute and Medical Clinic (United States)
Nicole Bernal, Univ. of California, Irvine (United States)
Adrien Ponticorvo, Beckman Laser Institute and Medical Clinic (United States)
Bernard Choi, Beckman Laser Institute and Medical Clinic (United States)
Anthony J. Durkin, Beckman Laser Institute and Medical Clinic (United States)


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