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Journal of Biomedical Optics

En face parametric imaging of tissue birefringence using polarization-sensitive optical coherence tomography
Author(s): Lixin Chin; Xiaojie Yang; Robert A. McLaughlin; Peter B. Noble; David D. Sampson
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Paper Abstract

A technique for generating en face parametric images of tissue birefringence from scans acquired using a fiber-based polarization-sensitive optical coherence tomography (PS-OCT) system utilizing only a single-incident polarization state is presented. The value of birefringence is calculated for each A-scan in the PS-OCT volume using a quadrature demodulation and phase unwrapping algorithm. The algorithm additionally uses weighted spatial averaging and weighted least squares regression to account for the variation in phase accuracies due to varying OCT signal-to-noise-ratio. The utility of this technique is demonstrated using a model of thermally induced damage in porcine tendon and validated against histology. The resulting en face images of tissue birefringence are more useful than conventional PS-OCT B-scans in assessing the severity of tissue damage and in localizing the spatial extent of damage.

Paper Details

Date Published: 3 June 2013
PDF: 6 pages
J. Biomed. Opt. 18(6) 066005 doi: 10.1117/1.JBO.18.6.066005
Published in: Journal of Biomedical Optics Volume 18, Issue 6
Show Author Affiliations
Lixin Chin, The Univ. of Western Australia (Australia)
Xiaojie Yang, The Univ. of Western Australia (Australia)
Robert A. McLaughlin, The Univ. of Western Australia (Australia)
Peter B. Noble, The Univ. of Western Australia (Australia)
David D. Sampson, The Univ. of Western Australia (Australia)


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