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Journal of Biomedical Optics

Deep-penetration photoacoustic array imaging of calcifications
Author(s): Tsai-Chu Hsiao; Yao-Yu Cheng; Wan-Ting Tein; Shih-Bin Luo; De-Yi Chiou; Ren-Jei Chung; Meng-Lin Li
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Paper Abstract

Calcifications are one of the most important indicators for early breast cancer detection. We explore the feasibility of deep-penetration photoacoustic (PA) imaging of calcifications based on a medical ultrasound array imaging platform. Intralipid and chicken breast phantoms embedded with different-sized hydroxyapatite (HA) particles, which are the major components of calcifications, were imaged to verify the equipment’s capability and penetration depth for the visualization of calcifications. An optimal near-infrared excitation wavelength was selected to maximize PA signals of HAs, resulting in a better HA signal-to-blood ratio. We demonstrated that PA imaging is capable of visualizing 0.5-mm HA particles at a depth of 3 cm in chicken breast phantoms. The noise-equivalent penetration depth of the system for visualizing 0.5-mm HA particles in the human breast was estimated to be about 2.9 to 3.5 cm, which is clinically relevant as calcifications are usually found at a depth of 0.6 to 3.0 cm. Moreover, the feasibility of differentiating HA from blood by the PA spectroscopic technique was presented and the mechanism of the HA signal generation was discussed. The results show that PA imaging is a promising technique for real-time visualization of breast calcifications.

Paper Details

Date Published: 3 June 2013
PDF: 6 pages
J. Biomed. Opt. 18(6) 066002 doi: 10.1117/1.JBO.18.6.066002
Published in: Journal of Biomedical Optics Volume 18, Issue 6
Show Author Affiliations
Tsai-Chu Hsiao, National Tsing Hua Univ. (Taiwan)
Yao-Yu Cheng, National Tsing Hua Univ. (Taiwan)
Wan-Ting Tein, Industrial Technology Research Institute (Taiwan)
Shih-Bin Luo, Industrial Technology Research Institute (Taiwan)
De-Yi Chiou, Industrial Technology Research Institute (Taiwan)
Ren-Jei Chung, National Taipei Univ. of Technology (Taiwan)
Meng-Lin Li, National Tsing Hua Univ. (Taiwan)

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