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Journal of Biomedical Optics

Use of Raman spectroscopy in the analysis of nickel allergy
Author(s): Javier Alda; Claudio Castillo-Martinez; Rodrigo Valdes-Rodriguez; Diana Hernández-Blanco; Benjamin Moncada; Francisco J. González
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Paper Abstract

Raman spectra of the skin of subjects with nickel allergy are analyzed and compared to the spectra of healthy subjects to detect possible biochemical differences in the structure of the skin that could help diagnose metal allergies in a noninvasive manner. Results show differences between the two groups of Raman spectra. These spectral differences can be classified using principal component analysis. Based on these findings, a novel computational technique to make a fast evaluation and classification of the Raman spectra of the skin is presented and proposed as a noninvasive technique for the detection of nickel allergy.

Paper Details

Date Published: 2 November 2012
PDF: 6 pages
J. Biomed. Opt. 18(6) 061206 doi: 10.1117/1.JBO.18.6.061206
Published in: Journal of Biomedical Optics Volume 18, Issue 6
Show Author Affiliations
Javier Alda, Univ. Complutense de Madrid (Spain)
Claudio Castillo-Martinez, Univ. Autónoma de San Luis Potosí (Mexico)
Rodrigo Valdes-Rodriguez, Univ. Autónoma de San Luis Potosí (Mexico)
Diana Hernández-Blanco, Univ. Autónoma de San Luis Potosí (Mexico)
Benjamin Moncada, Univ. Autónoma de San Luis Potosí (Mexico)
Francisco J. González, Univ. Autónoma de San Luis Potosi (Mexico)


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