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Journal of Biomedical Optics

Motion-contrast laser speckle imaging of microcirculation within tissue beds in vivo
Author(s): Rong Liu; Jia Qin; Ruikang K. Wang
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Paper Abstract

Laser speckle imaging is widely used to monitor functional blood perfusion within tissue beds in vivo but traditionally has difficulty visualizing small blood vessels even when the exposure time of the detector is long. We report a simple method that uses the motion contrast of dynamic speckle patterns to noninvasively visualize the distribution of blood flow within tissue beds in vivo. We experimentally demonstrate that the motion contrast can significantly suppress the effect of static scattering, leading to enhanced visibility of the functional blood vessels, including capillaries when compared to the traditional laser speckle contrast imaging.

Paper Details

Date Published: 26 June 2013
PDF: 3 pages
J. Biomed. Opt. 18(6) 060508 doi: 10.1117/1.JBO.18.6.060508
Published in: Journal of Biomedical Optics Volume 18, Issue 6
Show Author Affiliations
Rong Liu, Tianjin Univ. (China)
Jia Qin, Univ. of Washington (United States)
Ruikang K. Wang, Univ. of Washington (United States)

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