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Journal of Biomedical Optics • Open Access

Optical identification of subjects at high risk for developing breast cancer
Author(s): Paola Taroni; Giovanna Quarto; Antonio Pifferi; Francesca Ieva; Anna Maria Paganoni; Francesca Abbate; Nicola Balestreri; Simona Menna; Enrico Cassano; Rinaldo Cubeddu

Paper Abstract

A time-domain multiwavelength (635 to 1060 nm) optical mammography was performed on 147 subjects with recent x-ray mammograms available, and average breast tissue composition (water, lipid, collagen, oxy- and deoxyhemoglobin) and scattering parameters (amplitude a and slope b ) were estimated. Correlation was observed between optically derived parameters and mammographic density [Breast Imaging and Reporting Data System (BI-RADS) categories], which is a strong risk factor for breast cancer. A regression logistic model was obtained to best identify high-risk (BI-RADS 4) subjects, based on collagen content and scattering parameters. The model presents a total misclassification error of 12.3%, sensitivity of 69%, specificity of 94%, and simple kappa of 0.84, which compares favorably even with intraradiologist assignments of BI-RADS categories.

Paper Details

Date Published: 26 June 2013
PDF: 3 pages
J. Biomed. Opt. 18(6) 060507 doi: 10.1117/1.JBO.18.6.060507
Published in: Journal of Biomedical Optics Volume 18, Issue 6
Show Author Affiliations
Paola Taroni, Politecnico di Milano (Italy)
Giovanna Quarto, Politecnico di Milano (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)
Francesca Ieva, Politecnico di Milano (Italy)
Anna Maria Paganoni, Politecnico di Milano (Italy)
Francesca Abbate, Istituto Europeo di Oncologia (Italy)
Nicola Balestreri, Istituto Europeo di Oncologia (Italy)
Simona Menna, Istituto Europeo di Oncologia (Italy)
Enrico Cassano, Istituto Europeo di Oncologia (Italy)
Rinaldo Cubeddu, Istituto di Fotonica e Nanotecnologie (Italy)

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