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Journal of Biomedical Optics

Diffuse optical characterization of an exercising patient group with peripheral artery disease
Author(s): Rickson C. Mesquita; Mary E. Putt; Malavika Chandra; Guoqiang Yu; Xiaoman Xing; Sung Wan Han; Gwen Lech; Yu Shang; Turgut Durduran; Chao Zhou; Arjun G. Yodh; Emile R. Mohler
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Paper Abstract

Peripheral artery disease (PAD) is a common condition with high morbidity. While measurement of tissue oxygen saturation (S t O 2 ) has been demonstrated, this is the first study to assess both S t O 2 and relative blood flow (rBF) in the extremities of PAD patients. Diffuse optics is employed to measure hemodynamic response to treadmill and pedal exercises in 31 healthy controls and 26 patients. For S t O 2 , mild and moderate/severe PAD groups show pronounced differences compared with controls. Pre-exercise mean S t O 2 is lower in PAD groups by 9.3% to 10.6% compared with means of 63.5% to 66.2% in controls. For pedal, relative rate of return of S t O 2 to baseline is more rapid in controls (p<0.05 ). Patterns of rBF also differ among groups. After both exercises, rBF tend to occur at depressed levels among severe PAD patients compared with healthy (p<0.05 ); post-treadmill, rBF tend to occur at elevated levels among healthy compared with severe PAD patients (p<0.05 ). Additionally, relative rate of return to baseline S t O 2 is more rapid among subjects with reduced levels of depression in rBF (p=0.041 ), even after adjustment for ankle brachial index. This suggests a physiologic connection between rBF and oxygenation that can be measured using diffuse optics, and potentially employed as an evaluative tool in further studies.

Paper Details

Date Published: 24 May 2013
PDF: 12 pages
J. Biomed. Opt. 18(5) 057007 doi: 10.1117/1.JBO.18.5.057007
Published in: Journal of Biomedical Optics Volume 18, Issue 5
Show Author Affiliations
Rickson C. Mesquita, Univ. of Pennsylvania (United States)
Mary E. Putt, The Univ. of Pennsylvania Health System (United States)
Malavika Chandra, Univ. of Pennsylvania (United States)
Guoqiang Yu, Univ. of Kentucky (United States)
Xiaoman Xing, Univ. of Pennsylvania (United States)
Sung Wan Han, Univ. of Pennsylvania (United States)
Gwen Lech, Univ. of Pennsylvania (United States)
Yu Shang, Univ. of Kentucky (United States)
Turgut Durduran, ICFO - Institut de Ciències Fotòniques (Spain)
Chao Zhou, Lehigh Univ. (United States)
Arjun G. Yodh, Univ. of Pennsylvania (United States)
Emile R. Mohler, The Univ. of Pennsylvania Health System (United States)

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