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Journal of Biomedical Optics • Open Access

In vivo diffuse correlation spectroscopy investigation of the ocular fundus
Author(s): Stefano Cattini; Giovanni Staurenghi; Antonietta M. Gatti; Luigi Rovati

Paper Abstract

Diffuse correlation spectroscopy (DCS) measurements in vivo recorded from rabbits’ ocular fundus are presented. Despite the complexity of these ocular tissues, we provide a clear and simple demonstration of the DCS abilities to analyze variations in physiological quantities of clinical interest. Indeed, the reported experimental activities demonstrate that DCS can reveal both choroidal-flow and temperature variations and detect nano- and micro-aggregates in ocular fundus circulation. Such abilities can be of great interest both in fundamental research and practical clinical applications. The proposed measuring system can be useful in: (a) monitoring choroidal blood flow variations, (b) determining the end-point for photo-dynamic therapy and transpupillary thermo therapy and, (c) managing the dye injection and determining an end-point for dye-enhanced photothrombosis. Moreover, it could allow both diagnoses when the presence of nano- and micro-aggregates is related to specific diseases and verifying the effects of nanoparticle injection in nanomedicine. Even though the reported results demonstrate the applicability of DCS to investigate ocular fundus, a detailed and accurate investigation of the limits of detection is beyond the scope of this article.

Paper Details

Date Published: 2 May 2013
PDF: 15 pages
J. Biomed. Opt. 18(5) 057001 doi: 10.1117/1.JBO.18.5.057001
Published in: Journal of Biomedical Optics Volume 18, Issue 5
Show Author Affiliations
Stefano Cattini, Univ. degli Studi di Modena e Reggio Emilia (Italy)
Giovanni Staurenghi, Univ. degli Studi di Milano (Italy)
Antonietta M. Gatti, National Council of Research, Institute of Science and Technologies of Ceramic Materials (Italy)
Luigi Rovati, Univ. degli Studi di Modena e Reggio Emilia (Italy)

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