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Journal of Biomedical Optics • Open Access

Photosensitizer and light diffusion through dentin in photodynamic therapy
Author(s): Ana C. Nogueira; Ariane X. Graciano; Juliana Y. Nagata; Mitsue Fujimake; Raquel S. S. Terada; Antonio C. Bento; Nelson G. C. Astrath; Mauro L. Baesso

Paper Abstract

Photodynamic therapy has been considered a potential antimicrobial modality against oral infections, including dental caries. A model to estimate the penetration of both photosensitizers and light through human dentin, a factor of interest in photodynamic therapy, is proposed. The photoacoustic spectroscopy technique was used to evaluate in vitro dentin permeability of three different photosensitizers. Using the dentin optical absorption and scattering coefficients, it was possible to propose a semi-quantitative model predicting both photosensitizer and light doses within dentin. The graphic illustrations obtained provided guidelines that may be useful in photodynamic therapy protocols used as antimicrobial tools in caries lesions.

Paper Details

Date Published: 23 May 2013
PDF: 7 pages
J. Biomed. Opt. 18(5) 055004 doi: 10.1117/1.JBO.18.5.055004
Published in: Journal of Biomedical Optics Volume 18, Issue 5
Show Author Affiliations
Ana C. Nogueira, Univ. Estadual de Maringá (Brazil)
Ariane X. Graciano, Univ. Estadual de Maringá (Brazil)
Juliana Y. Nagata, Univ. Estadual de Maringá (Brazil)
Mitsue Fujimake, Univ. Estadual de Maringá (Brazil)
Raquel S. S. Terada, Univ. Estadual de Maringá (Brazil)
Antonio C. Bento, Univ. Estadual de Maringá (Brazil)
Nelson G. C. Astrath, Univ. Estadual de Maringá (Brazil)
Mauro L. Baesso, Univ. Estadual de Maringá (Brazil)


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