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Journal of Biomedical Optics • Open Access

Modeling of light scattering by biconcave and deformed red blood cells with the invariant imbedding T-matrix method
Author(s): Lei Bi; Ping Yang

Paper Abstract

The invariant imbedding T-matrix method (II-TM) is employed to simulate the optical properties of normal biconcave and deformed red blood cells (RBCs). The phase matrix elements of a RBC model computed with the II-TM are compared with their counterparts computed with the discrete-dipole approximation (DDA) method. As expected, the DDA results approach the II-TM results with an increase in the number of dipoles per incident wavelength. Computationally, the II-TM is faster than the DDA when multiple RBC orientations are considered. For a single orientation, the DDA is comparable with or even faster than the II-TM because the DDA efficiently converges for optically soft particles; however, the DDA method demands significantly more computer memory than the II-TM. After the applicability of the II-TM is numerically confirmed, a comparison is conducted of the optical properties of oxygenated and deoxygenated RBCs and of normal and deformed RBCs. The spectral variations of RBCs’ optical properties are investigated in the wavelength range from 0.25 to 1.0 μm. Furthermore, the statistically averaged phase matrix of spheres and biconcave RBCs are compared. Conducted numerical simulations suggest the applicability of the II-TM for the inverse light scattering analysis and radiative transfer simulations in blood.

Paper Details

Date Published: 7 May 2013
PDF: 14 pages
J. Biomed. Opt. 18(5) 055001 doi: 10.1117/1.JBO.18.5.055001
Published in: Journal of Biomedical Optics Volume 18, Issue 5
Show Author Affiliations
Lei Bi, Texas A&M Univ. (United States)
Ping Yang, Texas A&M Univ. (United States)

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