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Journal of Biomedical Optics • Open Access

Review of speckle and phase variance optical coherence tomography to visualize microvascular networks
Author(s): Mohammad S. Mahmud; David W. Cadotte; Barry Vuong; Carry Sun; Timothy W. H. Luk; Adrian Mariampillai; Victor X. D. Yang

Paper Abstract

High-resolution mapping of microvasculature has been applied to diverse body systems, including the retinal and choroidal vasculature, cardiac vasculature, the central nervous system, and various tumor models. Many imaging techniques have been developed to address specific research questions, and each has its own merits and drawbacks. Understanding, optimization, and proper implementation of these imaging techniques can significantly improve the data obtained along the spectrum of unique research projects to obtain diagnostic clinical information. We describe the recently developed algorithms and applications of two general classes of microvascular imaging techniques: speckle-variance and phase-variance optical coherence tomography (OCT). We compare and contrast their performance with Doppler OCT and optical microangiography. In addition, we highlight ongoing work in the development of variance-based techniques to further refine the characterization of microvascular networks.

Paper Details

Date Published: 24 April 2013
PDF: 14 pages
J. Biomed. Opt. 18(5) 050901 doi: 10.1117/1.JBO.18.5.050901
Published in: Journal of Biomedical Optics Volume 18, Issue 5
Show Author Affiliations
Mohammad S. Mahmud, Ryerson Univ. (Canada)
David W. Cadotte, Univ. of Toronto (Canada)
Barry Vuong, Ryerson Univ. (Canada)
Carry Sun, Ryerson Univ. (Canada)
Timothy W. H. Luk, Ryerson Univ. (Canada)
Adrian Mariampillai, Ryerson Univ. (Canada)
Victor X. D. Yang, Ryerson Univ. (Canada)

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