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Journal of Biomedical Optics • Open Access

350-μm side-view optical probe for imaging the murine brain in vivo from the cortex to the hypothalamus
Author(s): Jun Ki Kim; Jin Woo Choi; Seok Hyun A. Yun

Paper Abstract

Miniature endoscopic probes offer a solution for deep brain imaging by overcoming the limited depth of intravital microscopy. We describe a small-diameter (350 μm) graded-index optical probe with a side-view design for in vivo cellular imaging of the mammalian brain. The side-view probe provides a unique view of the vertical network of neurons and penetrating blood vessels. At a given insertion site, the translational and rotational scanning of the probe provides access to a large tissue area (<1  mm 2 ) across the cortex, hippocampus, thalamus, and hypothalamus.

Paper Details

Date Published: 29 April 2013
PDF: 4 pages
J. Biomed. Opt. 18(5) 050502 doi: 10.1117/1.JBO.18.5.050502
Published in: Journal of Biomedical Optics Volume 18, Issue 5
Show Author Affiliations
Jun Ki Kim, Wellman Ctr. for Photomedicine (United States)
Jin Woo Choi, Wellman Ctr. for Photomedicine (United States)
Seok Hyun A. Yun, Wellman Ctr. for Photomedicine (United States)

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