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Journal of Biomedical Optics • Open Access

In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography
Author(s): Anthony M. D> Lee; Keishi Ohtani; Calum MacAulay; Annette McWilliams; Tawimas Shaipanich; Victor X. D. Yang; Stephen Lam; Pierre Lane

Paper Abstract

For the first time, the use of fiber-optic color Doppler optical coherence tomography (CDOCT) to map in vivo the three-dimensional (3-D) vascular network of airway segments in human lungs is demonstrated. Visualizing the 3-D vascular network in the lungs may provide new opportunities for detecting and monitoring lung diseases such as asthma, chronic obstructive pulmonary disease, and lung cancer. Our CDOCT instrument employs a rotary fiberoptic probe that provides simultaneous two-dimensional (2- D) real-time structural optical coherence tomography (OCT) and CDOCT imaging at frame rates up to 12.5 frames per second. Controlled pullback of the probe allows 3-D vascular mapping in airway segments up to 50 mm in length in a single acquisition. We demonstrate the ability of CDOCT to map both small and large vessels. In one example, CDOCT imaging allows assignment of a feature in the structural OCT image as a large (∼1 mm diameter) blood vessel. In a second example, a smaller vessel (∼80 μm diameter) that is indistinguishable in the structural OCT image is fully visualized in 3-D using CDOCT.

Paper Details

Date Published: 25 April 2013
PDF: 4 pages
J. Biomed. Opt. 18(5) 050501 doi: 10.1117/1.JBO.18.5.050501
Published in: Journal of Biomedical Optics Volume 18, Issue 5
Show Author Affiliations
Anthony M. D> Lee, The BC Cancer Agency Research Ctr. (Canada)
Keishi Ohtani, The BC Cancer Agency Research Ctr. (Canada)
Calum MacAulay, The BC Cancer Agency Research Ctr. (Canada)
Annette McWilliams, The BC Cancer Agency Research Ctr. (Canada)
Tawimas Shaipanich, The BC Cancer Agency Research Ctr. (Canada)
Victor X. D. Yang, Ryerson Univ. (Canada)
Stephen Lam, The BC Cancer Agency Research Ctr. (Canada)
Pierre Lane, The BC Cancer Agency Research Ctr. (Canada)


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