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Journal of Biomedical Optics • Open Access

Concurrent multiscale imaging with magnetic resonance imaging and optical coherence tomography
Author(s): Chia-Pin Liang; Bo Yang; Il Kyoon Kim; George Makris; Jaydev Desai; Rao L. Gullapalli; Yu Chen

Paper Abstract

We develop a novel platform based on a tele-operated robot to perform high-resolution optical coherence tomography (OCT) imaging under continuous large field-of-view magnetic resonance imaging (MRI) guidance. Intra-operative MRI (iMRI) is a promising guidance tool for high-precision surgery, but it may not have sufficient resolution or contrast to visualize certain small targets. To address these limitations, we develop an MRI-compatible OCT needle probe, which is capable of providing microscale tissue architecture in conjunction with macroscale MRI tissue morphology in real time. Coregistered MRI/OCT images on ex vivo chicken breast and human brain tissues demonstrate that the complementary imaging scales and contrast mechanisms have great potential to improve the efficiency and the accuracy of iMRI procedure.

Paper Details

Date Published: 22 April 2013
PDF: 5 pages
J. Biomed. Opt. 18(4) 046015 doi: 10.1117/1.JBO.18.4.046015
Published in: Journal of Biomedical Optics Volume 18, Issue 4
Show Author Affiliations
Chia-Pin Liang, Univ. of Maryland, College Park (United States)
Bo Yang, Univ. of Maryland, College Park (United States)
Il Kyoon Kim, Univ. of Maryland, College Park (United States)
George Makris, Univ. of Maryland School of Medicine (United States)
Jaydev Desai, Univ. of Maryland, College Park (United States)
Rao L. Gullapalli, Univ. of Maryland School of Medicine (United States)
Yu Chen, Univ. of Maryland, College Park (United States)


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