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Journal of Biomedical Optics • Open Access

Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas
Author(s): Angelo Pierangelo; Sandeep Manhas; Abdelali Benali; Clément Fallet; Jean-Laurent Totobenazara; Maria Rosaria Antonelli; Tatiana Novikova; Brice Gayet; Antonello De Martino; Pierre Validire

Paper Abstract

This work is devoted to a first exploration of Mueller polarimetric imaging for the detection of residual cancer after neoadjuvant treatment for the rectum. Three samples of colorectal carcinomas treated by radiochemotherapy together with one untreated sample are analyzed ex vivo before fixation in formalin by using a multispectral Mueller polarimetric imaging system operated from 500 to 700 nm. The Mueller images, analyzed using the Lu-Chipmann decomposition, show negligible diattenuation and retardation. The nonirradiated rectum exhibits a variation of depolarization with cancer evolution stage. At all wavelengths on irradiated samples, the contrast between the footprint of the initial tumor and surrounding healthy tissue is found to be much smaller for complete tumor regression than when a residual tumor is present, even at volume fractions of the order of 5%. This high sensitivity is attributed to the modification of stromal collagen induced by the cancer. The depolarization contrast between treated cancer and healthy tissue is found to increase monotonously with the volume fraction of residual cancer in the red part of the spectrum. Polarimetric imaging is a promising technique for detecting short-time small residual cancers, which is valuable information for pathological diagnosis and patient management by clinicians.

Paper Details

Date Published: 23 April 2013
PDF: 10 pages
J. Biomed. Opt. 18(4) 046014 doi: 10.1117/1.JBO.18.4.046014
Published in: Journal of Biomedical Optics Volume 18, Issue 4
Show Author Affiliations
Angelo Pierangelo, Ecole Polytechnique (France)
Sandeep Manhas, Ecole Polytechnique (France)
Abdelali Benali, Institut Mutualiste Montsouris (France)
Clément Fallet, Ecole Polytechnique (France)
Jean-Laurent Totobenazara, Ecole Polytechnique (France)
Maria Rosaria Antonelli, Ecole Polytechnique (France)
Tatiana Novikova, Ecole Polytechnique (France)
Brice Gayet, Institut Mutualiste Montsouris (France)
Antonello De Martino, Ecole Polytechnique (France)
Pierre Validire, Institut Mutualiste Montsouris (France)

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