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Journal of Biomedical Optics • Open Access

Imaging of pharmacokinetic rates of indocyanine green in mouse liver with a hybrid fluorescence molecular tomography/x-ray computed tomography system
Author(s): Guanglei Zhang; Fei Liu; Bin Zhang; Yun He; Jianwen Luo; Jing Bai

Paper Abstract

Pharmacokinetic rates have the potential to provide quantitative physiological and pathological information for biological studies and drug development. Fluorescence molecular tomography (FMT) is an attractive imaging tool for three-dimensionally resolving fluorophore distribution in small animals. In this letter, pharmacokinetic rates of indocyanine green (ICG) in mouse liver are imaged with a hybrid FMT and x-ray computed tomography (XCT) system. A recently developed FMT method using structural priors from an XCT system is adopted to improve the quality of FMT reconstruction. In the in vivo experiments, images of uptake and excretion rates of ICG in mouse liver are obtained, which can be used to quantitatively evaluate liver function. The accuracy of the results is validated by a fiber-based fluorescence measurement system.

Paper Details

Date Published: 17 April 2013
PDF: 4 pages
J. Biomed. Opt. 18(4) 040505 doi: 10.1117/1.JBO.18.4.040505
Published in: Journal of Biomedical Optics Volume 18, Issue 4
Show Author Affiliations
Guanglei Zhang, Tsinghua Univ. School of Medicine (China)
Fei Liu, Tsinghua Univ. School of Medicine (China)
Bin Zhang, Tsinghua Univ. School of Medicine (China)
Yun He, Tsinghua Univ. School of Medicine (China)
Jianwen Luo, Tsinghua Univ. School of Medicine (China)
Jing Bai, Tsinghua Univ. School of Medicine (China)


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