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Journal of Biomedical Optics • Open Access

Compact high power barium nitrite crystal-based Raman laser at 1197 nm for photoacoustic imaging of fat
Author(s): Rui Li; Mikhail N. Slipchenko; Pu Wang; Ji-Xin Cheng

Paper Abstract

Photoacoustic imaging employing molecular overtone vibration as a contrast mechanism opens a new avenue for bond-selective imaging of deep tissues. Broad use of this modality is, however, hampered by the extremely low conversion efficiency of optical parametric oscillators at the overtone transition wavelengths. To overcome such a barrier, we demonstrate the construction and use of a compact, barium nitrite crystal-based Raman laser for photoacoustic imaging of C–H overtone vibrations. Using a 5-ns NdYAG laser as the pumping source, up to 21.4 mJ pulse energy at 1197 nm was generated, corresponding to a conversion efficiency of 34.8%. Using the 1197 nm pulses, three-dimensional photoacoustic imaging of intramuscular fat was demonstrated.

Paper Details

Date Published: 27 March 2013
PDF: 4 pages
J. Biomed. Opt. 18(4) 040502 doi: 10.1117/1.JBO.18.4.040502
Published in: Journal of Biomedical Optics Volume 18, Issue 4
Show Author Affiliations
Rui Li, Purdue Univ. (United States)
Mikhail N. Slipchenko, Purdue Univ. (United States)
Pu Wang, Purdue Univ. (United States)
Ji-Xin Cheng, Purdue Univ. (United States)

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