Share Email Print

Journal of Biomedical Optics • Open Access

Evidence of a heterogeneous tissue oxygenation: renal ischemia/reperfusion injury in a large animal model
Author(s): Nicole J. Crane; Scott W. Huffman; Mehrdad Alemozaffar; Frederick A. Gage; Ira W. Levin; Eric A. Elster

Paper Abstract

Renal ischemia that occurs intraoperatively during procedures requiring clamping of the renal artery (such as renal procurement for transplantation and partial nephrectomy for renal cancer) is known to have a significant impact on the viability of that kidney. To better understand the dynamics of intraoperative renal ischemia and recovery of renal oxygenation during reperfusion, a visible reflectance imaging system (VRIS) was developed to measure renal oxygenation during renal artery clamping in both cooled and warm porcine kidneys. For all kidneys, normothermic and hypothermic, visible reflectance imaging demonstrated a spatially distinct decrease in the relative oxy-hemoglobin concentration (%HbO 2 ) of the superior pole of the kidney compared to the middle or inferior pole. Mean relative oxy-hemoglobin concentrations decrease more significantly during ischemia for normothermic kidneys compared to hypothermic kidneys. VRIS may be broadly applicable to provide an indicator of organ ischemia during open and laparoscopic procedures.

Paper Details

Date Published: 1 March 2013
PDF: 8 pages
J. Biomed. Opt. 18(3) 035001 doi: 10.1117/1.JBO.18.3.035001
Published in: Journal of Biomedical Optics Volume 18, Issue 3
Show Author Affiliations
Nicole J. Crane, Naval Medical Research Ctr. (United States)
Scott W. Huffman, Western Carolina Univ. (United States)
Mehrdad Alemozaffar, Univ. of Southern California (United States)
Frederick A. Gage, Naval Medical Research Ctr. (United States)
Ira W. Levin, National Institutes of Health (United States)
Eric A. Elster, Naval Medical Research Ctr. (United States)

© SPIE. Terms of Use
Back to Top