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Journal of Biomedical Optics • Open Access

Imaging of biological tissues with pixel-level analysis of second-order susceptibility

Paper Abstract

We discuss the recent advances in the development and applications of second-order susceptibility as a contrast mechanism in optical microscopy for biological tissues. We review nonlinear optical methods and approaches for differentiation of tissue structures and discrimination of normal and pathological skin tissues, which have been demonstrated for the potential use in clinical diagnosis. In addition, the potential of second-order susceptibility imaging, encompassing applications in differentiating various types of collagen molecules for clinical diagnosis, is demonstrated. Finally, we discuss future development and application of this technique.

Paper Details

Date Published: 22 November 2012
PDF: 10 pages
J. Biomed. Opt. 18(3) 031102 doi: 10.1117/1.JBO.18.3.031102
Published in: Journal of Biomedical Optics Volume 18, Issue 3
Show Author Affiliations
Po-Sheng Hu, National Cheng Kung Univ. (Taiwan)
Ara Ghazaryan, National Taiwan Univ. (Taiwan)
Vladimir A. Hovhannisyan, National Taiwan Univ. (Taiwan)
Shean-Jen Chen, National Cheng Kung Univ. (Taiwan)
Yang-Fang Chen, National Taiwan Univ. (Taiwan)
Chang-Seok Kim, Pusan National Univ. (Korea, Republic of)
Tsung-Hua Tsai, Far Eastern Memorial Hospital (Taiwan)
Chen-Yuan Dong, National Taiwan Univ. (Taiwan)

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