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Journal of Biomedical Optics • Open Access

Imaging and quantifying Brownian motion of micro- and nanoparticles using phase-resolved Doppler variance optical coherence tomography
Author(s): Chang Soo Kim; Wenjuan Qi; Jun Zhang; Young Jik Kwon; Zhongping Chen

Paper Abstract

Different types and sizes of micro- and nanoparticles have been synthesized and developed for numerous applications. It is crucial to characterize the particle sizes. Traditional dynamic light scattering, a predominant method used to characterize particle size, is unable to provide depth resolved information or imaging functions. Doppler variance optical coherence tomography (OCT) measures the spectral bandwidth of the Doppler frequency shift due to the Brownian motion of the particles utilizing the phase-resolved approach and can provide quantitative information about particle size. Spectral bandwidths of Doppler frequency shifts for various sized particles were quantified and were demonstrated to be inversely proportional to the diameter of the particles. The study demonstrates the phase-resolved Doppler variance spectral domain OCT technique has the potential to be used to investigate the properties of particles in highly scattering media.

Paper Details

Date Published: 20 March 2013
PDF: 4 pages
J. Biomed. Opt. 18(3) 030504 doi: 10.1117/1.JBO.18.3.030504
Published in: Journal of Biomedical Optics Volume 18, Issue 3
Show Author Affiliations
Chang Soo Kim, Beckman Laser Institute and Medical Clinic (United States)
Wenjuan Qi, Beckman Laser Institute and Medical Clinic (United States)
Jun Zhang, Beckman Laser Institute and Medical Clinic (United States)
Young Jik Kwon, Univ. of California, Irvine (United States)
Zhongping Chen, Beckman Laser Institute and Medical Clinic (United States)


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