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Journal of Biomedical Optics

Continuous haematic pH monitoring in extracorporeal circulation using a disposable florescence sensing element
Author(s): Luca Ferrari; Luigi Rovati; Paola Fabbri; Francesco Pilati
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Paper Abstract

During extracorporeal circulation (ECC), blood is periodically sampled and analyzed to maintain the blood-gas status of the patient within acceptable limits. This protocol has well-known drawbacks that may be overcome by continuous monitoring. We present the characterization of a new pH sensor for continuous monitoring in ECC. This monitoring device includes a disposable fluorescence-sensing element directly in contact with the blood, whose fluorescence intensity is strictly related to the pH of the blood. In vitro experiments show no significant difference between the blood gas analyzer values and the sensor readings; after proper calibration, it gives a correlation of R<0.9887 , and measuring errors were lower than the 3% of the pH range of interest (RoI) with respect to a commercial blood gas analyzer. This performance has been confirmed also by simulating a moderate ipothermia condition, i.e., blood temperature 32°C, frequently used in cardiac surgery. In ex vivo experiments, performed with animal models, the sensor is continuously operated in an extracorporeal undiluted blood stream for a maximum of 11 h. It gives a correlation of R<0.9431 , and a measuring error lower than the 3% of the pH RoI with respect to laboratory techniques.

Paper Details

Date Published: 1 February 2013
PDF: 10 pages
J. Biomed. Opt. 18(2) 027002 doi: 10.1117/1.JBO.18.2.027002
Published in: Journal of Biomedical Optics Volume 18, Issue 2
Show Author Affiliations
Luca Ferrari, Univ. degli Studi di Modena e Reggio Emilia (Italy)
Luigi Rovati, Univ. degli Studi di Modena e Reggio Emilia (Italy)
Paola Fabbri, Univ. degli Studi di Modena e Reggio Emilia (Italy)
Francesco Pilati, Univ. degli Studi di Modena e Reggio Emilia (Italy)

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