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Journal of Biomedical Optics

Color-matched and fluorescence-labeled esophagus phantom and its applications
Author(s): Chenying Yang; Vivian Hou; Leonard Y. Nelson; Eric J. Seibel
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Paper Abstract

We developed a stable, reproducible three-dimensional optical phantom for the evaluation of a wide-field endoscopic molecular imaging system. This phantom mimicked a human esophagus structure with flexibility to demonstrate body movements. At the same time, realistic visual appearance and diffuse spectral reflectance properties of the tissue were simulated by a color matching methodology. A photostable dye-in-polymer technology was applied to represent biomarker probed “hot-spot” locations. Furthermore, fluorescent target quantification of the phantom was demonstrated using a 1.2 mm ultrathin scanning fiber endoscope with concurrent fluorescence-reflectance imaging.

Paper Details

Date Published: 12 February 2013
PDF: 12 pages
J. Biomed. Opt. 18(2) 026020 doi: 10.1117/1.JBO.18.2.026020
Published in: Journal of Biomedical Optics Volume 18, Issue 2
Show Author Affiliations
Chenying Yang, Univ. of Washington (United States)
Vivian Hou, Univ. of Washington (United States)
Leonard Y. Nelson, Univ. of Washington (United States)
Eric J. Seibel, Univ. of Washington (United States)

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