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Journal of Biomedical Optics

In vivo inflammation mapping of periodontal disease based on diffuse reflectance spectral imaging: a clinical study
Author(s): Chandra Sekhar Prasanth; Joseph Betsy; Jayaraj L. Jayanthi; Unni G. Nisha; Janam Prasantila; Narayanan Subhash
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Paper Abstract

Since conventional techniques using periodontal probes have inherent drawbacks in the diagnosis of different grades of gingival inflammation, development of noninvasive screening devices becomes significant. Diffuse reflectance (DR) spectra recorded with white light illumination is utilized to detect periodontal inflammation from the oxygenated hemoglobin absorption ratio R620/R575. A multispectral imaging system is utilized to record narrow-band DR images at 575 and 620 nm from the anterior sextant of the gingivia of 15 healthy volunteers and 25 patients (N=40 ). An experienced periodontist assesses the level of gingival inflammation at each site through periodontal probing and assigns diagnosis as healthy, mild, moderate, or severe inflammation. The DR image ratio R620/R575 computed for each pixel (8-µm resolution) from the monochrome images is pseudo-color-mapped to identify gingival inflammation sites. The DR image ratio values at each site are compared with clinical diagnosis to estimate the specificity and sensitivity of the DR imaging technique in inflammation mapping. The high diagnostic accuracy is utilized to detect underlying inflammation in six patients with a previous history of periodontitis.

Paper Details

Date Published: 12 February 2013
PDF: 7 pages
J. Biomed. Opt. 18(2) 026019 doi: 10.1117/1.JBO.18.2.026019
Published in: Journal of Biomedical Optics Volume 18, Issue 2
Show Author Affiliations
Chandra Sekhar Prasanth, Ctr. for Earth Science Studies (India)
Joseph Betsy, Government Dental College, Thiruvananthapuram (India)
Jayaraj L. Jayanthi, The Regional Cancer Ctr Thiruvananthapuram (India)
Unni G. Nisha, Ctr. for Earth Science Studies (India)
Janam Prasantila, Government Dental College, Thiruvananthapuram (India)
Narayanan Subhash, Ctr. for Earth Science Studies (India)


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