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Journal of Biomedical Optics • Open Access

Photoacoustic contrast imaging of biological tissues with nanodiamonds fabricated for high near-infrared absorbance
Author(s): Ti Zhang; Huizhong Cui; Chia-Yi Fang; Long-Jyun Su; Shenqiang Ren; Huan-Cheng Chang; Xinmai Yang; M. Laird Forrest

Paper Abstract

Radiation-damaged nanodiamonds (DNDs) are potentially ideal optical contrast agents for photoacoustic (PA) imaging in biological tissues due to their low toxicity and high optical absorbance. PA imaging contrast agents have been limited to quantum dots and gold particles, since most existing carbon-based nanoparticles, including fluorescent nanodiamonds, do not have sufficient optical absorption in the near-infrared (NIR) range. A new DND by He + ion beam irradiation with very high NIR absorption was synthesized. These DNDs produced a 71-fold higher PA signal on a molar basis than similarly dimensioned gold nanorods, and 7.1 fmol of DNDs injected into rodents could be clearly imaged 3 mm below the skin surface with PA signal enhancement of 567% using an 820-nm laser wavelength.

Paper Details

Date Published: 12 February 2013
PDF: 7 pages
J. Biomed. Opt. 18(2) 026018 doi: 10.1117/1.JBO.18.2.026018
Published in: Journal of Biomedical Optics Volume 18, Issue 2
Show Author Affiliations
Ti Zhang, The Univ. of Kansas (United States)
Huizhong Cui, The Univ. of Kansas (United States)
Chia-Yi Fang, Academia Sinica (Taiwan)
Long-Jyun Su, Academia Sinica (Taiwan)
Shenqiang Ren, The Univ. of Kansas (United States)
Huan-Cheng Chang, Academia Sinica (Taiwan)
Xinmai Yang, The Univ. of Kansas (United States)
M. Laird Forrest, The Univ. of Kansas (United States)


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