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Journal of Biomedical Optics

Diffuse optical tomography in the presence of a chest wall
Author(s): Han Y. Ban; David R. Busch; Saurav Pathak; Frank A. Moscatelli; Manabu Machida; John C. Schotland; Vadim A. Markel; Arjun G. Yodh
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Paper Abstract

Diffuse optical tomography (DOT) has been employed to derive spatial maps of physiologically important chromophores in the human breast, but the fidelity of these images is often compromised by boundary effects such as those due to the chest wall. We explore the image quality in fast, data-intensive analytic and algebraic linear DOT reconstructions of phantoms with subcentimeter target features and large absorptive regions mimicking the chest wall. Experiments demonstrate that the chest wall phantom can introduce severe image artifacts. We then show how these artifacts can be mitigated by exclusion of data affected by the chest wall. We also introduce and demonstrate a linear algebraic reconstruction method well suited for very large data sets in the presence of a chest wall.

Paper Details

Date Published: 7 February 2013
PDF: 12 pages
J. Biomed. Opt. 18(2) 026016 doi: 10.1117/1.JBO.18.2.026016
Published in: Journal of Biomedical Optics Volume 18, Issue 2
Show Author Affiliations
Han Y. Ban, Univ. of Pennsylvania (United States)
David R. Busch, Univ. of Pennsylvania (United States)
Saurav Pathak, Univ. of Pennsylvania (United States)
Frank A. Moscatelli, Swarthmore College (United States)
Manabu Machida, Univ. of Michigan (United States)
John C. Schotland, Univ. of Michigan (United States)
Vadim A. Markel, Univ. of Pennsylvania School of Medicine (United States)
Arjun G. Yodh, Univ. of Pennsylvania (United States)

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