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Journal of Biomedical Optics

Single-cell photoacoustic thermometry
Author(s): Liang Gao; Lidai Wang; Chiye Li; Yan Liu; Haixin Ke; Chi Zhang; Lihong V. Wang
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Paper Abstract

A novel photoacoustic thermometric method is presented for simultaneously imaging cells and sensing their temperature. With three-seconds-per-frame imaging speed, a temperature resolution of 0.2°C was achieved in a photo-thermal cell heating experiment. Compared to other approaches, the photoacoustic thermometric method has the advantage of not requiring custom-developed temperature-sensitive biosensors. This feature should facilitate the conversion of single-cell thermometry into a routine lab tool and make it accessible to a much broader biological research community.

Paper Details

Date Published: 1 February 2013
PDF: 6 pages
J. Biomed. Opt. 18(2) 026003 doi: 10.1117/1.JBO.18.2.026003
Published in: Journal of Biomedical Optics Volume 18, Issue 2
Show Author Affiliations
Liang Gao, Washington Univ. in St. Louis (United States)
Lidai Wang, Washington Univ. School of Medicine in St. Louis (United States)
Chiye Li, Washington Univ. in St. Louis (United States)
Yan Liu, Washington Univ. in St. Louis (United States)
Haixin Ke, Washington Univ. in St. Louis (United States)
Chi Zhang, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


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