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Journal of Biomedical Optics

Analysis and modeling of an ultrasound-modulated guide star to increase the depth of focusing in a turbid medium
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Paper Abstract

The effects of strong scattering in tissue limit the depth to which light may be focused. However, it has been shown that scattering may be reduced utilizing adaptive optics with a focused ultrasound (US) beam guidestar. The optical signal traveling through the US beam waist is frequency shifted and may be isolated with demodulation. This paper utilizes a multiphysics simulation to model the optical and US interactions in both synthetic tissue and random scattering media. The results illustrate that optical energy may be focused within a turbid medium utilizing a US guidestar. The results also suggest that optical energy travels preferentially along optical channels within a turbid medium.

Paper Details

Date Published: 12 February 2013
PDF: 9 pages
J. Biomed. Opt. 18(2) 025004 doi: 10.1117/1.JBO.18.2.025004
Published in: Journal of Biomedical Optics Volume 18, Issue 2
Show Author Affiliations
Joseph L. Hollmann, Northeastern Univ. (United States)
Roarke Horstmeyer, California Institute of Technology (United States)
Changhuei Yang, California Institute of Technology (United States)
Charles A. DiMarzio, Northeastern Univ. (United States)


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