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Journal of Biomedical Optics • Open Access

Fluorescence molecular tomography of an animal model using structured light rotating view acquisition

Paper Abstract

In recent years, an increasing effort has been devoted to the optimization of acquisition and reconstruction schemes for fluorescence molecular tomography (FMT). In particular, wide-field structured illumination and compression of the measured images have enabled significant reduction of the data set and, consequently, a decrease in both acquisition and processing times. FMT based on this concept has been recently demonstrated on a cylindrical phantom with a rotating-view scheme that significantly increases the reconstruction quality. In this work, we generalize the rotating-view scheme to arbitrary geometries and experimentally demonstrate its applicability to murine models. To the best of our knowledge this is the first time that FMT based on a rotating-view scheme with structured illumination and image compression has been applied to animals.

Paper Details

Date Published: 23 January 2013
PDF: 3 pages
J. Biomed. Opt. 18(2) 020503 doi: 10.1117/1.JBO.18.2.020503
Published in: Journal of Biomedical Optics Volume 18, Issue 2
Show Author Affiliations
Nicolas Ducros, Politecnico di Milano (Italy)
Andrea Bassi, Politecnico di Milano (Italy)
Gianluca Valentini, Politecnico di Milano (Italy)
Gianfranco L. Canti, Univ. degli Studi di Milano (Italy)
Simon R. Arridge, Univ. College London (United Kingdom)
Cosimo D'Andrea, Politecnico di Milano (Italy)

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