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Journal of Biomedical Optics

Influence of different energy densities of laser phototherapy on oral wound healing
Author(s): Vivian Petersen Wagner; Luise Meurer; Marco Antonio Trevizani Martins; Chris Krebs Danilevicz; Alessandra Selinger Magnusson; Márcia Martins Marques; Manoel Sant’Ana Filho; Cristiane Helena Squarize; Manoela Domingues Martinsa
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Paper Abstract

The aim of the present prospective study was to evaluate the impact of laser phototherapy (LPT) on the healing of oral ulcers. Different power densities were used on oral wounds in Wistar rats (n=72) randomly divided into three groups: control (0  J/cm2), 4  J/cm2 laser, and 20  J/cm2 laser. Ulcers (3 mm in diameter) were made on the dorsum of the tongue with a punch. Irradiation with an indium-gallium-aluminum-phosphide laser (660 nm; output power: 40 mW; spot size: 0.04  cm2) was performed once a day in close contact with the ulcer for 14 consecutive days. A statistically significant acceleration in healing time was found with wounds treated with 4  J/cm2 LPT. Moreover, striking differences were found in the ulcer area, healing percentage, degree of reepithelialization, and collagen deposition. The most significant changes occurred after 5 days of irradiation. Based on the conditions employed in the present study, LPT is capable of accelerating the oral mucosa wound-healing process. Moreover, faster and more organized reepithelialization and tissue healing of the oral mucosa were achieved with an energy density of 4  J/cm2 in comparison to 20  J/cm2.

Paper Details

Date Published: 10 December 2013
PDF: 7 pages
J. Biomed. Opt. 18(12) 128002 doi: 10.1117/1.JBO.18.12.128002
Published in: Journal of Biomedical Optics Volume 18, Issue 12
Show Author Affiliations
Vivian Petersen Wagner, Univ. Federal do Rio Grande do Sul (Brazil)
Luise Meurer, Univ. Federal do Rio Grande do Sul (Brazil)
Marco Antonio Trevizani Martins, Univ. Federal do Rio Grande do Sul (Brazil)
Chris Krebs Danilevicz, Univ. Federal do Rio Grande do Sul (Brazil)
Alessandra Selinger Magnusson
Márcia Martins Marques, Univ. de São Paulo (Brazil)
Manoel Sant’Ana Filho, Univ. Federal do Rio Grande do Sul (Brazil)
Cristiane Helena Squarize, Univ. of Michigan (United States)
Manoela Domingues Martinsa, Univ. Federal do Rio Grande do Sul (Brazil)


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