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Journal of Biomedical Optics

Noninvasive monitoring of gas in the lungs and intestines of newborn infants using diode lasers: feasibility study
Author(s): Patrik Lundin; Emilie Krite Svanberg; Lorenzo Cocola; Märta Lewander Xu; Gabriel Somesfalean; Stefan Andersson-Engels; John Jahr; Vineta Fellman; Katarina Svanberg; Sune Svanberg
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Paper Abstract

Preterm newborn infants have a high morbidity rate. The most frequently affected organs where free gas is involved are the lungs and intestines. In respiratory distress syndrome, both hyperexpanded and atelectatic (collapsed) areas occur, and in necrotizing enterocolitis, intramural gas may appear in the intestine. Today, these conditions are diagnosed with x-ray radiography. A bed-side, rapid, nonintrusive, and gas-specific technique for in vivo gas sensing would improve diagnosis. We report the use of noninvasive laser spectroscopy, for the first time, to assess gas content in the lungs and intestines of three full-term infants. Water vapor and oxygen were studied with two low-power diode lasers, illuminating the skin and detecting light a few centimeters away. Water vapor was easily detected in the intestines and was also observed in the lungs. The relatively thick chest walls of the infants prevented detection of the weaker oxygen signal in this study. However, results from a previous phantom study, together with scaling of the results presented here to the typical chest-wall thickness of preterm infants, suggest that oxygen also should be detectable in their lungs.

Paper Details

Date Published: 20 December 2013
PDF: 8 pages
J. Biomed. Opt. 18(12) 127005 doi: 10.1117/1.JBO.18.12.127005
Published in: Journal of Biomedical Optics Volume 18, Issue 12
Show Author Affiliations
Patrik Lundin, Lund Univ. (Sweden)
Emilie Krite Svanberg, Lund Univ. (Sweden)
Lorenzo Cocola, IFN-CNR LUXOR Lab. (Italy)
Märta Lewander Xu
Gabriel Somesfalean, Lund Univ. (Sweden)
Stefan Andersson-Engels, Lund Univ. (Sweden)
John Jahr, Lund Univ. Hospital (Sweden)
Vineta Fellman, Lund Univ. Hospital (Sweden)
Katarina Svanberg, Lund Univ. Hospital (Sweden)
Sune Svanberg, Lund Univ. (Sweden)


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