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Journal of Biomedical Optics

Schlieren laser Doppler flowmeter for the human optical nerve head with the flicker stimuli
Author(s): Martial H. Geiser; Frederic Truffer; Hugo Evequoz; Hafid Khayi; Benjamin Mottet; Christophe Chiquet
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Paper Abstract

We describe a device to measure blood perfusion for the human optic nerve head (ONH) based on laser Doppler flowmetry (LDF) with a flicker stimuli of the fovea region. This device is self-aligned for LDF measurements and includes near-infrared pupil observation, green illumination, and observation of the ONH. The optical system of the flowmeter is based on a Schlieren arrangement which collects only photons that encounter multiple scattering and are back-scattered out of the illumination point. LDF measurements are based on heterodyne detection of Doppler shifted back-scattered light. We also describe an automated analysis of the LDF signals which rejects artifacts and false signals such as blinks. By using a Doppler simulator consisting of a lens and a rotating diffusing wheel, we demonstrate that velocity and flow vary linearly with the speed of the wheel. A cohort of 12 healthy subjects demonstrated that flicker stimulation induces an increase of 17.8% of blood flow in the ONH.

Paper Details

Date Published: 2 December 2013
PDF: 6 pages
J. Biomed. Opt. 18(12) 127001 doi: 10.1117/1.JBO.18.12.127001
Published in: Journal of Biomedical Optics Volume 18, Issue 12
Show Author Affiliations
Martial H. Geiser, HES-SO Valais (Switzerland)
Frederic Truffer, HES-SO Valais (Switzerland)
Hugo Evequoz, HES-SO Valais (Switzerland)
Hafid Khayi, Grenoble Univ. Hospital (France)
Benjamin Mottet, Grenoble Univ. Hospital (France)
Christophe Chiquet, Grenoble Univ. Hospital (France)

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