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Journal of Biomedical Optics • Open Access

Optical coherence tomography assessment of vessel wall degradation in thoracic aortic aneurysms
Author(s): Eusebio Real; Alma Eguizabal; Alejandro Pontón; Marta Calvo Diez; Jose Fernando Val-Bernal; Marta Mayorga; José M. Revuelta; José M. López-Higuera; Olga M. Conde

Paper Abstract

Optical coherence tomography images of human thoracic aorta from aneurysms reveal elastin disorders and smooth muscle cell alterations when visualizing the media layer of the aortic wall. These disorders can be employed as indicators for wall degradation and, therefore, become a hallmark for diagnosis of risk of aneurysm under intraoperative conditions. Two approaches are followed to evaluate this risk: the analysis of the reflectivity decay along the penetration depth and the textural analysis of a two-dimensional spatial distribution of the aortic wall backscattering. Both techniques require preprocessing stages for the identification of the air–sample interface and for the segmentation of the media layer. Results show that the alterations in the media layer of the aortic wall are better highlighted when the textural approach is considered and also agree with a semiquantitative histopathological grading that assesses the degree of wall degradation. The correlation of the co-occurrence matrix attains a sensitivity of 0.906 and specificity of 0.864 when aneurysm automatic diagnosis is evaluated with a receiver operating characteristic curve.

Paper Details

Date Published: 4 December 2013
PDF: 11 pages
J. Biomed. Opt. 18(12) 126003 doi: 10.1117/1.JBO.18.12.126003
Published in: Journal of Biomedical Optics Volume 18, Issue 12
Show Author Affiliations
Eusebio Real, Univ. de Cantabria (Spain)
Alma Eguizabal, Univ. de Cantabria (Suriname)
Alejandro Pontón, Univ. Hospital Marques de Valdecilla (Spain)
Marta Calvo Diez, Univ. Hospital Marques de Valdecilla (Spain)
Jose Fernando Val-Bernal, Univ. Hospital Marques de Valdecilla (Spain)
Marta Mayorga, Univ. Hospital Marques de Valdecilla (Spain)
José M. Revuelta, Univ. Hospital Marques de Valdecilla (Spain)
José M. López-Higuera, Univ. de Cantabria (Spain)
Olga M. Conde, Univ. de Cantabria (Spain)

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