Share Email Print

Journal of Biomedical Optics • Open Access

Digital image correlation–based optical coherence elastography
Author(s): Cuiru Sun; Beau A. Standish; Barry Vuong; Xiao-Yan Wen; Victor X. D. Yang

Paper Abstract

Optical coherence elastography (OCE) provides deformation or material properties, mapping of soft tissue. We aim to develop a robust speckle tracking OCE technique with improved resolution and accuracy. A digital image correlation (DIC)-based OCE technique was developed by combining an advanced DIC algorithm with optical coherence tomography (OCT). System calibration and measurement error evaluation demonstrated that this DIC-based OCE technique had a resolution of ∼0.6  μm displacement and <0.5% strain measurement in the axial scan direction. The measured displacement ranged from 0.6 to 150 μm, obtained via phantom imaging. The capability of the DIC-based OCE technique, for differentiation of stiffness, was evaluated by imaging a candle gel phantom with an irregularly shaped stiff inclusion. OCE imaging of a chicken breast sample differentiated the fat, membrane, and muscle layers. Strain elastograms of an aneurysm sample showed heterogeneity of the tissue and clear contrast between the adventitia and media. These promising results demonstrated the capability of the DIC-based OCE for the characterization of the various components of the tissue sample. Further improvement of the system will be conducted to make this OCE technique a practical tool for measuring and differentiating material properties of soft tissue.

Paper Details

Date Published: 17 December 2013
PDF: 9 pages
J. Biomed. Opt. 18(12) 121515 doi: 10.1117/1.JBO.18.12.121515
Published in: Journal of Biomedical Optics Volume 18, Issue 12
Show Author Affiliations
Cuiru Sun, Univ. of Toronto (Canada)
Beau A. Standish, Ryerson Univ. (Canada)
Barry Vuong, Ryerson Univ. (Canada)
Xiao-Yan Wen, Univ. of Toronto (Canada)
Victor X. D. Yang, Ryerson Univ. (Canada)

© SPIE. Terms of Use
Back to Top