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Journal of Biomedical Optics

From supersonic shear wave imaging to full-field optical coherence shear wave elastography
Author(s): Amir Nahas; Mickael Tanter; Thu-Mai Nguyen; Jean-Marie Chassot; Mathias Fink; A. Claude Boccara
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Paper Abstract

Elasticity maps of tissue have proved to be particularly useful in providing complementary contrast to ultrasonic imaging, e.g., for cancer diagnosis at the millimeter scale. Optical coherence tomography (OCT) offers an endogenous contrast based on singly backscattered optical waves. Adding complementary contrast to OCT images by recording elasticity maps could also be valuable in improving OCT-based diagnosis at the microscopic scale. Static elastography has been successfully coupled with full-field OCT (FF-OCT) in order to realize both micrometer-scale sectioning and elasticity maps. Nevertheless, static elastography presents a number of drawbacks, mainly when stiffness quantification is required. Here, we describe the combination of two methods: transient elastography, based on speed measurements of shear waves induced by ultrasonic radiation forces, and FF-OCT, an en face OCT approach using an incoherent light source. The use of an ultrafast ultrasonic scanner and an ultrafast camera working at 10,000 to 30,000  images/s made it possible to follow shear wave propagation with both modalities. As expected, FF-OCT is found to be much more sensitive than ultrafast ultrasound to tiny shear vibrations (a few nanometers and micrometers, respectively). Stiffness assessed in gel phantoms and an ex vivo rat brain by FF-OCT is found to be in good agreement with ultrasound shear wave elastography.

Paper Details

Date Published: 19 December 2013
PDF: 9 pages
J. Biomed. Opt. 18(12) 121514 doi: 10.1117/1.JBO.18.12.121514
Published in: Journal of Biomedical Optics Volume 18, Issue 12
Show Author Affiliations
Amir Nahas, Institut Langevin (France)
Mickael Tanter, Institut Langevin (France)
Thu-Mai Nguyen, Institut Langevin (France)
Jean-Marie Chassot, Institut Langevin (France)
Mathias Fink, Institut Langevin (France)
A. Claude Boccara, Institut Langevin (France)


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